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Health and non-health benefits and equity impacts of individual-level economic relief programs: A Scoping Review

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A preprint titled Health and non-health benefits and equity impacts of individual-level economic relief programs during epidemics/pandemics in high income settings: A Scoping Review, by Adeteju Ogunbameru and colleagues at the University of Toronto, York University, University Health Network and other institutions. The cover page lists the keywords pandemic preparedness, epidemics, COVID-19, infectious disease and equity, and gives a posted date of October 12th, 2023. It states that the work is licensed under a Creative Commons Attribution 4.0 International License and that a version was published at BMC Public Health on August 5th, 2024.

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Health And Non Health Benefits And Equity Impacts Of Individual Level Economic Relief Programs During Epidemics Pandemic

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Health and non-health benefits and equity impacts of individual-level
economic relief programs during epidemics/pandemics in high income
settings: A Scoping Review
Adeteju Ogunbameru



 University of Toronto
Gebremedhin BeedMariam Gebretekle
 University of Toronto
Adrianna Perryman
 York University – Keele Campus
Marian Hassan
 University Health Network
Ashley Farrell
 University Health Network
Kaun Liu
 University of Toronto
Sharmistha Mishra
 Centre of Urban Health Solutions, Michael’s Hospital
Beate Sander
 University Health Network



Research Article

Keywords: pandemic preparedness, epidemics, COVID-19, Infectious disease, equity

Posted Date: October 12th, 2023

DOI: https://doi.org/10.21203/rs.3.rs-3408285/v1

License:   This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License

Additional Declarations: No competing interests reported.


Version of Record: A version of this preprint was published at BMC Public Health on August 5th, 2024. See the published version at
https://doi.org/10.1186/s12889-024-19493-8.




                                                                        Page 1/20
Abstract
Background
Economic relief programs are strategies designed to sustain societal welfare and population health during a regional or global scale infectious disease
outbreak. While economic relief programmes are considered essential during a regional or global health crisis, there is no clear consensus in the literature
about their health and non-health benefits and their impact on promoting equity.


Methods
We conducted a scoping review, searching eight electronic databases from January 01, 2001, to April 3, 2023, using text words and subject headings for
recent pathogens (coronavirus (COVID-19), Ebola, Influenza, Middle East Respiratory Syndrome (MERS), severe acute respiratory syndrome (SARS), HIV, West
Nile, and Zika), and economic relief programs; but restricted eligibility to high-income countries and selected diseases due to volume. Title and abstract
screening were conducted by trained reviewers and Distiller AI software. Data were extracted in duplicates by two trained reviewers using a pretested form,
and key findings were charted using a narrative approach.


Results
We identified 27,263 de-duplicated records, of which 50 were eligible. Included studies were on COVID-19 and Influenza, published between 2014 and 2023.
Zero eligible studies were on MERS, SARS, Zika, Ebola, or West Nile Virus. We identified seven program types of which cash transfer (n = 12) and vaccination
or testing incentive (n = 9) were most common. Individual-level economic relief programs were reported to have varying degrees of impact on public health
measures, and sometimes affected population health outcomes. Expanding paid sick leave programs had the highest number of studies reporting health-
related outcomes and positively impacted public health measures (isolation, vaccination uptake) and health outcomes (case counts and the utilization of
healthcare services). Equity impact was most often reported for cash transfer programs and incentive for vaccination programs. Positive effects on general
well-being and non-health outcomes included improved mental well-being and quality of life, food security, financial resilience, and job security.



Conclusions
Our findings suggest that individual-level economic relief programs can have significant impacts on public health measures, population health outcomes and
equity. As countries prepare for future pandemics, our findings provide evidence to stakeholders to recognize health equity as a fundamental public health
goal when designing pandemic preparedness policies.


BACKGROUND
Infectious disease epidemics and pandemics can result in catastrophic economic collapse and disastrous human, social, and health consequences (1).
Populations experiencing social and economic marginalization have consistently experienced the highest risk of infection, disease severity and death (2–4).
Across high-income settings, racially minoritized individuals experienced disproportionate burden of COVID-19, H1N1 influenza, and tuberculosis (3, 5, 6);
driven by how systemic racism has shaped occupational risks, housing, and health care (6).

Individual-level economic relief programs are economic interventions implemented by governments, institutions, or private sources during an epidemic or
pandemic to limit the disproportional health and economic consequences often experienced by populations at higher risk of the disease (e.g., low- and
modest-income families, families with children, homeless population, and indigenous persons), support public measures and improve population health (7).
Programs implemented during the COVID-19 pandemic included paid sick leave, caregiver and childcare benefits, unemployment compensations for
furloughed workers, and food supply and direct cash payments to low-income earners (7).

Pandemic-informed individual level economic relief policies are intended to encourage changes in human behaviour and motivate individuals to make healthy
choices that impact health and overall well-being; (8) however, we found very limited evidence on the health-related benefits of individual level economic
relief programs in our exploratory review, conducted in few electronic databases in September 2020 to assess the feasibility of a broader review.

Because the implementation individual level economic relief programs are often costly (7) and there is often a debate about their impact during outbreaks
(9), we systematically chart their health and non-health benefits, and equity impacts to inform pandemic preparedness planning.

Our objective is to map the current state of the literature on individual-level economic relief programs during infectious disease outbreaks and their impact on
the effectiveness of public health measures, individual and population health, non-health outcomes, and health equity during regional or global scale
infectious disease outbreaks. Our review questions are:

  1. What are the types of individual-level economic relief programs implemented during an infectious disease outbreak?
  2. How and to what extent do pandemic/epidemic individual-level economic relief programs impact the effectiveness of public health measures during
     epidemics?
  3. How and to what extent do changes in public health measures associated with pandemic/epidemic individual-level economic relief programs impact
    health outcomes?


                                                                          Page 2/20
  4. Do health benefits associated with pandemic/epidemic individual-level economic relief programs differ across demographic and social groups, and
     place of residence? If so, how?
  5. What are the non-health outcomes assessed in eligible studies identified?
  6. What are the limitations associated with pandemic/epidemic individual-level economic relief programs?
  7. What are the knowledge gaps in the literature in relation to the questions above?


METHODS
We followed the updated Arksey and O’Malley’s framework on conducting scoping review (10, 11) and the Preferred Reporting Items in Systematic Reviews
and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) reporting guideline (12).

Our protocol is available at doi: 10.1136/bmjopen-2021-057386. (13)


Search strategy
An information specialist developed our comprehensive search strategy using text words and Medical Subject Headings (MeSH) terms. In the original search
strategy, from January 1, 2001, to October 8, 2021, we searched concepts relating to pandemic/epidemic infectious diseases (specifically, coronaviruses,
influenza A, SARS, MERS, HIV/AIDS, Zika, Ebola and West Nile) and economic relief programs (e.g., government financing, public assistance, food assistance,
medical assistance, workers compensation, social welfare, charities, and childcare). We restricted our search to 2001 onwards because of the differences in
living standard and public health systems over time. We updated our search on April 3, 2023. For the updated search, we excluded HIV terms from the search
strategy due to the volume of HIV/AIDS publications during the original screening =. The original search strategy was developed in the Ovid Medline and then
translated to other databases. Both MEDLINE search strategies are reported in the appendix.

We searched eight databases - MEDLINE, OVID E-pub Ahead of Print In-Process & Other Non-Indexed Citations, EMBASE, Cochrane CENTRAL, all on the
OvidSP platform; EconLit, CINAHL, on the EBSCO platform; ISI Web of Science on the Clarivate platform, and Global Index Medicus from the World Health
Organization (WHO). We manually searched the reference lists of eligible studies to ensure we do not miss relevant articles.

Our search excluded clinical conferences, comments, editorials, letters, and animal studies. No study design, language or country restriction was employed in
our search strategy.

Study screening and Data extraction
De-duplication, and title and abstract screening were conducted using the Distiller SR software, including the artificial intelligence (AI) simulation tool that
automates the title and abstract screening process (14). Four trained reviewers conducted the title and abstract screening in parallel without using Distiller
AI. Distiller AI was used at the end of the screening process to check for screening errors among excluded records. Retrieved records were tagged by country
type (high-income or low-and-middle-income) and disease (HIV, COVID-19, Zika, Ebola, West Nile, MERS, SARS, or influenza A (H1N1 and H2N2). We excluded
commentaries, book chapters, conference abstracts with no full text, study protocols, and business targeted economic relief programs.

Following title and abstract screening, we restricted study eligibility to COVID-19, Zika, Ebola, West Nile, MERS, SARS, or influenza A (H1N1 and H2N2) and
high-income settings due to volume (see Fig. 1 for details on the excluded studies). We also excluded non-English articles due to limited translation
resources.

Full text screening and data extraction were conducted in duplicates by two trained reviewers using Microsoft Excel software. Disagreements were resolved
through discussions until consensus was reached. Data abstraction was conducted using a pre-tested template. Data elements included study and
population characteristics (study objective, study design, study population), infectious disease outbreak description (name of outbreak and time of outbreak),
economic relief program description (eligible population, program and equity considerations used in assessing eligibility and program implementation time
period), public health measure outcomes, population health outcomes, general health outcomes, equity impacts (by variables such as demographics, social
and jurisdiction), and non-health outcomes. Data extraction and synthesis on equity impact was guided by the PROGRESS-Plus framework to ensure we
systematically consider health equity under relevant dimensions, including demography, social factors, disability, and sexual orientation (15). Individual level
economic relief programs were categorized by the nature of the program and intended population. For examples, monetary incentive programs directed to
increase vaccine uptake or testing were categorized as “incentive for vaccination or testing” program; fiscal stimulus directed to workers when ill/exposed to
encourage quarantine/isolation was termed “expanded paid sick leave”; employment insurance payment to furloughed workers or unemployed individuals
was termed “unemployed assistance”; direct cash payment to support individuals and households was termed “cash transfer” food supply programs to
communities, schools, households was categorized as “food assistance”; two or more individual-level economic relief program groups simultaneously was
termed “mixed program” and “others” program category which included subsidy program and expanded child tax credit program.

Full details of the data elements extracted is described in our protocol (13).
Data charting
We summarized public health measures, health, non-health measures and equity impact associated with individual-level economic programs using a
narrative approach and visual plots. In the equity-impact analysis, we provided details on how outcomes differed by equity variables.


RESULTS

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Our initial and updated search yielded 27,263 de-duplicated records from the eight databases. After title and abstract screening, we retrieved 415 records for
full-text screening. Following the amended eligibility criteria, we excluded 227 studies from low- and middle-income countries and 45 studies on HIV from
high-income countries. We assessed the full text of 143 studies and excluded 93 records. The reasons for exclusions included: no quantitative assessment
of the individual-level economic relief program (n = 33), not an individual-level economic relief program (n = 23), and book/commentary/report/opinion/
research letters/conference abstract/media release (n = 25). Fifty studies were found eligible for final review. The PRISMA flow diagram is shown in Fig. 1.

Insert Fig. 1

Studies and Program characteristics
Eligible studies were published between 2014 and 2023. Ninety percent (90%) were COVID-19 related (n = 45) and others were on influenza (n = 5). We did not
identify eligible studies on MERS, SARS, Zika, Ebola, or West Nile virus. Seventy-three percent of included studies were conducted in the United States of
America (n = 36) (16–50), followed by Japan (51–53), South Korea (43, 54, 55), Australia (56, 57), Canada (58, 59), Chile, Israel, Spain, and Singapore (60–63).
Two-third of eligible studies used a survey study design (17, 19, 22, 28, 29, 32–34, 36, 38, 43–47, 50–54, 57, 59, 61, 63–67); others included quasi-experiment
(25, 41), simulation (20, 22, 27, 55, 60, 69), observational (26, 38, 49, 56), and randomized control trial design (42, 48, 58, 62).

We identified 28 unique individual-level economic relief programs among eligible studies and categorized them into seven groups.

Of the 50 eligible studies, three sets of seven studies reported on COVID-19 related unemployment assistance programs (18, 19, 22, 23, 26, 30, 47), COVID-19
food assistance programs (22, 24, 28, 40, 43, 44, 46), and expanded paid sick leave (16, 25, 34–36, 39, 49) in the context of COVID-19 pandemic and Influenza
epidemic. Eleven eligible studies reported on COVID-19 cash transfer programs (17, 20, 45, 48, 50, 52, 54, 56, 58, 68, 69); nine studies evaluated vaccine and
testing incentives during COVID-19 pandemic and Influenza epidemic (29, 33, 37, 38, 42, 55, 57, 62, 63); seven assessed mixed programs (27, 31, 32, 51, 59–
61), three of which combined unemployment assistance and cash transfer programs (27, 31, 59). Two COVID-19 studies reported on programs in the “other
“category (41, 53).

Figure 2 presents the program and study characteristics as a heat map.

Insert Fig. 2
Health, non-health, and equity outcomes of individual-level economic relief programs
All eligible studies reported on at least one review outcome. Studies on expanding paid sick leave programs reported the most health-related outcomes (n =
7) (16, 25, 34–36, 39, 49). The impact on non-health outcomes was commonly assessed for cash transfer programs (n = 10) (17, 20, 48, 50, 52, 54, 56, 58, 68,
69). Incentive for vaccination program studies contributed majorly to the equity data (n = 3) (29, 42, 62).

Figure 3 presents a Coxcomb chart of study outcomes by individual-level economic relief program type.

Insert Fig. 3
Health impacts
Thirty-six of the 50 eligible studies were designed to evaluate the health impact of an economic relief program (16–18, 25, 29, 32–42, 45, 49, 51, 53–55, 57,
58, 62, 63).

Impact on public health measures. Fifteen out of 50 studies were designed to examine the effect of economic relief programs on public health measures (25,
29, 33, 34, 36–39, 42, 53, 57, 58, 62, 63, 68).

Three studies, reporting on programs of expanded paid sick leave (n = 1), domestic travel subsidy (n = 1), and cash transfer (n = 1), found that economic relief
programs could have a positive, neutral, or negative impact on social distancing, depending on program type (39, 53, 58). Two studies reported that expanded
paid sick leave increased the probability of workers isolating when sick by 15% (25) and increased the time spent away from work when sick by 1.10 days
(35). Expanding paid sick leave significantly increased vaccination coverage during influenza disease outbreaks by 10–15% (34, 36). Vaccine incentives were
reported to significantly increase vaccination rates by 7% − 23.2% (29, 37, 62) in the context of COVID-19 and influenza outbreaks. A domestic travel subsidy
program had no impact on masking practice, respiratory hygiene practice & surface disinfection (53).

Population health outcomes based on programs’ impact on public health measures were evaluated by eight studies (29, 36, 38, 39, 53, 55, 58). Health
outcomes reported on included symptom and case counts, infection transmission, healthcare visits and herd immunity. The economic relief programs were
cash transfers (58), expanded paid sick leave (16, 35, 36, 39), incentives for vaccination/testing (29, 55), and domestic travel subsidy (53). Expanded paid
sick leave and incentive for vaccination/testing were associated with positive health outcomes (16, 29, 35, 36, 39, 55) while cash transfer and domestic travel
subsidy were linked to neutral (58) and negative health outcomes (53) respectively.

General well-being outcomes were reported in thirteen studies (17, 18, 32, 34, 36, 41, 43, 45, 49, 51, 58, 63, 67). The economic relief program types assessed
included cash transfer (n = 4), unemployment assistance (n = 1), paid sick leave (n = 1), food assistance program (n = 2) and expanded child tax credit (n = 1).
Cash transfer, unemployment assistance, food assistance, and expanded child tax credit were reported to have a positive impact on mental well-being in
seven studies (17, 18, 32, 41, 43, 45, 67). Paid sick leave was associated with intention to seek medical care; food assistance programs were associated with
healthier eating and improved intention to seek medical care when ill (34, 67).



                                                                             Page 4/20
Non-health impacts
Thirty-three of the 50 (60%) eligible studies reported non-health outcomes (17–20, 22, 23, 26, 28, 31, 36, 38, 52, 54, 58–61, 65–66, 69, 72). Economic relief
programs had a positive impact on non-health measures including food security, financial resilience/savings/financial security, consumption spending and
debt payment, housing/mortgage payment and job security. Programs included cash transfer (n = 10), unemployment assistance (n = 10), incentive for
vaccination (n = 1), food assistance (n = 6), mixed (n = 4) and expanded paid sick leave (n = 2).
Equity impacts
Nine of the 50 (18%) eligible studies reported on the equity impact of the individual level economic relief programs (29, 32, 36, 41, 42, 45, 53, 58, 62). Program
types assessed included cash transfer (n = 2), incentive for vaccination (n = 3), mixed (n = 1), expanded paid sick leave (n = 1), and “other” (n = 2). The equity
factors considered were demographics (age, and race), socioeconomic status (employment), and jurisdiction.

Health outcomes associated with cash transfer programs differed across demographic factors (race and age) in two studies (58, 45). Cash transfer reduced
the incidence of COVID-19 symptoms among 50 years or older (45) and improved financial savings (a proxy for improved mental health) among Hispanics
(58).

In three studies assessing the effect of incentive for vaccination, health outcomes significantly differed by race, age, and employment (29, 42, 62). Vaccine
incentive increased vaccination rates among Blacks and non-working elderly in COVID-19 pandemic and influenza epidemic (29, 62). Vaccine incentive
reduced vaccine uptake among 40 years and older in a COVID-19 study (42).

Expanded child tax credit program reduced anxiety symptoms among Blacks and Hispanics (41). Domestic travel subsidy increased the incidence of COVID-
19 symptoms among young participants (53).

Table 1 presents the health, equity impact and non-health outcomes reported in eligible studies.




                                                                            Page 5/20
                                                                    Table 1
                      Summary of the health, non-health, and equity outcomes of individual level economic relief programs.
Author,     Country    Study Design     Economic          Public health       Population         General well-     Non-health         Equity impact
year                                    relief program    measure             health             being             outcomes
                                        type              impact              outcomes
                                                                              associated with
                                                                              public health
                                                                              measure
                                                                              impact

Persaud     Canada     Randomized       Cash transfer     No difference       No difference      Self-reported     Cash transfers     Incidence of
2021                   controlled                                             in symptom         health did not    did not reduce     COVID-19 like
                       trial                              in the number       count after 2      differ between    food insecurity    symptoms
                                                          of close            weeks (ratio of    groups after 2    (80%vs 71%)        reduced in
                                                          contacts            means 0.83;        weeks                                those aged
                                                          outside of the      95% CI 0.56 to                                          50 years or
                                                          household           1.24, p = 0.34)                                         older, but not
                                                          between groups                                                              in those < 50
                                                                                                                                      years (p =
                                                          (Rate ratio 1.10                                                            0.005)
                                                          95% CI 0.83 to
                                                          1.46)

Tsai 2020   USA        Survey           Cash transfer     NA                  NA                 Economic          Economic           NA
                                                                                                 Impact            Impact
                                                                                                 Payment           Payment was
                                                                                                 recipients        associated with
                                                                                                 were more         fewer problems
                                                                                                 likely to have    paying daily
                                                                                                 tested positive   expenses.
                                                                                                 or been
                                                                                                 untested for
                                                                                                 COVID-19 and
                                                                                                 less likely to
                                                                                                 screen
                                                                                                 positive for
                                                                                                 current major
                                                                                                 depression,
                                                                                                 generalized
                                                                                                 anxiety
                                                                                                 disorder, past
                                                                                                 2-week
                                                                                                 suicidal
                                                                                                 ideation,
                                                                                                 COVID-19 era-
                                                                                                 related stress,
                                                                                                 and any illicit
                                                                                                 drug use
                                                                                                 compared to
                                                                                                 those who did
                                                                                                 not receive the
                                                                                                 payment

Pichler     USA        Survey           Expanded paid     NA                  Relative to the    NA                NA                 NA
2020                   (difference in   sick leave                            mean number
                       difference                                             of new cases
                       analysis)                                              for the control
                                                                              group, the
                                                                              study model
                                                                              predicted a
                                                                              decrease of
                                                                              417 new
                                                                              COVID-19
                                                                              cases (56%)
                                                                              after the
                                                                              introduction of
                                                                              Families First
                                                                              Coronavirus
                                                                              Response Act.

Berkowitz   USA        Survey           Unemployment      NA                  NA                 Receiving         The risk of food   NA
2020                   (difference in   assistance                                               unemployment      insufficiency
                       difference                                                                insurance         was lower for
                       analysis)                                                                 benefits was      those who
                                                                                                 associated        received
                                                                                                 with lower risk   unemployment
                                                                                                 for unmet         insurance
                                                                                                 health-related    compared to
                                                                                                 social needs,     those who did
                                                                                                 and               not. ( p <
                                                                                                 depressive        0.0001)
                                                                                                 and anxiety
                                                                                                 symptoms.

Lee 2021    South      Simulation       Incentive for     NA                  Study              NA                NA                 NA
            Korea                       testing                               epidemiological
                                                                              model
                                                                              predicted an
                                                                              increase in the

                                                                 Page 6/20
Author,      Country   Study Design   Economic         Public health      Population          General well-     Non-health   Equity impact
year                                  relief program   measure            health              being             outcomes
                                      type             impact             outcomes
                                                                          associated with
                                                                          public health
                                                                          measure
                                                                          impact
                                                                          proportion of
                                                                          confirmed
                                                                          infected
                                                                          patients out of
                                                                          unidentified
                                                                          infected people
                                                                          in the
                                                                          susceptible-
                                                                          unidentified
                                                                          infected-
                                                                          confirmed
                                                                          stimulated
                                                                          population

Schneider    USA       Quasi-         Expanded paid    15% reduction      NA                  NA                NA           NA
2021                   experimental   sick leave       in the
                                                       proportion of
                                                       workers who
                                                       reported
                                                       working while
                                                       sick

Ikeda 2021   Japan     Survey         Mixed            NA                 NA                  the Special       NA           NA
                                                                                              Cash Payment
                                                                                              was
                                                                                              associated
                                                                                              with better
                                                                                              health related
                                                                                              quality of life
                                                                                              (95% CI): 0.05
                                                                                              (0.03 to 0.08)

Messer       USA       Survey         Incentive for    Coupled            Program could       NA                NA           Moderate
2021                                  vaccination      incentives         bring the US                                       incentive
                                                       increase           vaccination                                        ($1500)
                                                       estimated          levels from 58%                                    increased
                                                       vaccination        to more than                                       vaccine
                                                       rates by 7–8%.     65% —                                              uptake
                                                       (P = 0.03)         substantially                                      among Black
                                                                          closer to the                                      respondents
                                                                          rates needed to                                    to 68 per cent
                                                                          reach herd                                         (± 16%).
                                                                          immunity.                                          Similar trend
                                                                                                                             was found for
                                                                                                                             Latino
                                                                                                                             respondents.
                                                                                                                             Low income
                                                                                                                             was
                                                                                                                             associated
                                                                                                                             with low
                                                                                                                             vaccine
                                                                                                                             uptake. The
                                                                                                                             middle-
                                                                                                                             income
                                                                                                                             groups
                                                                                                                             appeared
                                                                                                                             most
                                                                                                                             responsive to
                                                                                                                             the vaccine
                                                                                                                             incentive.

Miyawaki     Japan     Survey         Domestic         Program            Program             NA                NA           Higher
2021                                  travel subsidy   participants       participants                                       incidence
                                                       were more likely   exhibited                                          rates of
                                                       than non-          higher                                             COVID-19 like
                                                       participants to    incidence of                                       symptoms
                                                       engage in risky    high fever                                         were more
                                                       behaviour          (adjusted OR:                                      salient
                                                       (visiting          1.83; 95% CI                                       among young
                                                       restaurants,       1.34 to 2.48),                                     program
                                                       bars/nightclubs,   sore throat                                        participants
                                                       at least once);    (aOR 2.09; 95%                                     compared to
                                                       no impact on       CI 1.37 to 3.19),                                  non-
                                                       masking            cough (aOR                                         participants
                                                       practice,          1.96; 95% CI
                                                       respiratory        1.26 to 3.01),
                                                       hygiene            headache (aOR
                                                       practice &         1.24; 95% CI
                                                       surface            1.08 to 1.44)
                                                       disinfection.      and smell and
                                                                          taste disorder

                                                             Page 7/20
Author,      Country   Study Design    Economic           Public health      Population         General well-    Non-health   Equity impact
year                                   relief program     measure            health             being            outcomes
                                       type               impact             outcomes
                                                                             associated with
                                                                             public health
                                                                             measure
                                                                             impact
                                                                             aOR 1.98; 95%
                                                                             CI 1.15 to 3.40)
                                                                             compared with
                                                                             non-
                                                                             participants.

Fan 2020     USA       Survey          Mixed                                                    The              NA           Unemployed
                                                                                                unemployed                    working-age
                                                                                                working-age                   population
                                                                                                population                    with
                                                                                                receiving                     government
                                                                                                government                    assistance
                                                                                                assistance                    residing in
                                                                                                had a higher                  urban areas
                                                                                                frequency of                  showed
                                                                                                feeling                       significantly
                                                                                                nervous,                      higher
                                                                                                lonely, and                   frequency
                                                                                                hopeless                      feeling
                                                                                                compared to                   nervous,
                                                                                                those without                 lonely, and
                                                                                                assistance                    hopeless
                                                                                                                              compared to
                                                                                                                              their non-
                                                                                                                              urban
                                                                                                                              counterparts

Acharya      USA       Survey          Incentive for      lottery            NA                 NA               NA           NA
2021                                   vaccination        programs were
                                                          associated with
                                                          an increase of
                                                          an average
                                                          23.12%
                                                          increment in the
                                                          new daily
                                                          vaccination
                                                          rate.

Algara       USA       Retrospective   Incentive for      positively         NA                 NA               NA           NA
2023                   observational   vaccination        influence
                                                          vaccine
                                                          preferences
                                                          among the
                                                          mass public
                                                          and all partisan
                                                          groups

Andersen     USA       Survey          Expanded paid      reduced the        Weekly COVID-      NA               NA           NA
2022                                   sick leave         number of          19 incidence
                                                          hours people       decreased by
                                                          were not at        7.7 log points.
                                                          home by a 0.38
                                                          h or 22.9-min
                                                          and the
                                                          proportion of
                                                          individuals
                                                          away from
                                                          home for more
                                                          than eight
                                                          hours per day
                                                          declined by
                                                          1.8% point.

Barr 2021    USA       Survey          Food               NA                 NA                 The              NA           NA
                                       assistance                                               community-
                                                                                                based free
                                                                                                meal
                                                                                                distribution
                                                                                                program led to
                                                                                                healthier
                                                                                                eating and
                                                                                                reduced stress
                                                                                                among
                                                                                                participants

Batra 2023   USA       Quasi-          Expanded           NA                 NA                 Program          NA           Adults of
                       experimental    child tax credit                                         resulted in                   Black,
                                                                                                fewer                         Hispanic, and
                                                                                                depressive                    other racial
                                                                                                and anxiety                   and ethnic
                                                                                                symptoms                      backgrounds
                                                                                                among low-                    demonstrated

                                                                Page 8/20
Author,      Country     Study Design    Economic         Public health      Population        General well-      Non-health   Equity impact
year                                     relief program   measure            health            being              outcomes
                                         type             impact             outcomes
                                                                             associated with
                                                                             public health
                                                                             measure
                                                                             impact
                                                                                               income adults.                  greater
                                                                                               (13.3 percent                   reductions in
                                                                                               reduction from                  anxiety
                                                                                               baseline                        symptoms
                                                                                               anxiety levels                  compared to
                                                                                               (25.5 percent)                  non-Hispanic
                                                                                                                               White adults
                                                                                                                               with children.

Jacobson     USA         Randomized      Incentive for    Increases          NA                NA                 NA           Financial
2022                     controlled      vaccination      vaccination                                                          incentives
                         trial                            rates between                                                        reduced
                                                          1.0% and 1.6%                                                        vaccination
                                                          points.                                                              rates in both
                                                                                                                               older
                                                                                                                               individuals
                                                                                                                               (ages 40 and
                                                                                                                               over) and
                                                                                                                               those who
                                                                                                                               indicated they
                                                                                                                               supported
                                                                                                                               Trump in the
                                                                                                                               2020
                                                                                                                               presidential
                                                                                                                               election.

Jun'd 2022   Australia   Survey          Incentive for    Program            NA                NA                 NA           NA
                                         vaccination      participants
                                                          were 2.27 (95%
                                                          CI 1.73 to 2.99)
                                                          times more
                                                          likely to be
                                                          vaccinated.

Kim 2021     USA         Survey          Food             NA                 NA                Implementing       NA           NA
                                         assistance                                            SNAP subsidy
                                                                                               after
                                                                                               unemployment
                                                                                               insurance
                                                                                               expiration was
                                                                                               predicted to
                                                                                               lead to a 3-fold
                                                                                               higher risk of
                                                                                               anxiety and
                                                                                               depressive
                                                                                               symptoms
                                                                                               among those
                                                                                               experiencing
                                                                                               considerable
                                                                                               financial
                                                                                               hardship
                                                                                               versus no
                                                                                               hardship (P
                                                                                               < .001),

Liu 2023     USA         Survey          Cash transfer    NA                 NA                There was a        NA           African
                                                                                               negative                        American
                                                                                               association                     households
                                                                                               between the                     were less
                                                                                               amount of                       likely to
                                                                                               stimulus                        increase
                                                                                               received and                    spending,
                                                                                               financial                       Hispanic
                                                                                               hardship (a                     households
                                                                                               proxy for                       were more
                                                                                               mental well-                    likely to
                                                                                               being)                          increase
                                                                                               experienced                     savings.
                                                                                               by
                                                                                               respondents
                                                                                               during the
                                                                                               COVID-19
                                                                                               pandemic.

Pollack      USA         Longitudinal    Expanded paid    States with pre-   NA                NA                 NA           NA
2022                     observational   sick leave       existing paid
                                                          sick leave
                                                          policies
                                                          exhibited a
                                                          greater drop in
                                                          mobility (P <
                                                          001).

                                                                Page 9/20
Author,     Country     Study Design   Economic         Public health       Population         General well-     Non-health         Equity impact
year                                   relief program   measure             health             being             outcomes
                                       type             impact              outcomes
                                                                            associated with
                                                                            public health
                                                                            measure
                                                                            impact

Shmueli     Israel      Survey         Incentive for    Program did not     NA                 Incentives        NA                 NA
2022                                   vaccination      increase the                           such as
                                                        probability of                         monetary
                                                        getting                                rewards or the
                                                        vaccination                            green pass did
                                                        immediately.                           not

                                                                                               increase the
                                                                                               probability of
                                                                                               getting
                                                                                               vaccination
                                                                                               immediately.

Dudley      USA         Survey         Incentive for    the odds of         NA                 NA                NA                 NA
2021                                   vaccination      reporting
                                                        receiving
                                                        influenza
                                                        vaccine
                                                        compared to
                                                        the control
                                                        group was 0.22
                                                        (95%CI: 0.09–
                                                        0.51)

Yue 2021    Singapore   Randomized     Incentive for    increased           NA                 NA                NA                 The effect of
                        controlled     vaccination      participation in                                                            increasing
                        trial                           vaccination                                                                 incentives on
                                                        from 4.5–7.5%                                                               influenza
                                                        (P = 0.001).                                                                vaccination
                                                                                                                                    rates was
                                                                                                                                    significant in
                                                                                                                                    nonworking
                                                                                                                                    elderly group
                                                                                                                                    than those
                                                                                                                                    who
                                                                                                                                    worked(P = <
                                                                                                                                    0.001) and
                                                                                                                                    differed by
                                                                                                                                    ethnicity (P =
                                                                                                                                    0.001), socio-
                                                                                                                                    economic
                                                                                                                                    status(P = <
                                                                                                                                    0.0001),
                                                                                                                                    household
                                                                                                                                    size (0.009),
                                                                                                                                    and a
                                                                                                                                    measure of
                                                                                                                                    social
                                                                                                                                    resilience (P
                                                                                                                                    < 0.001)

Zhai 2018   USA         Survey         Expanded paid    Compared to         NA                 Paid sick leave   NA                 NA
                                       sick leave       workers with no                        was
                                                        paid sick leave,                       independently
                                                        influenza                              associated
                                                        vaccination                            with seeking
                                                        coverage                               treatment for
                                                        estimates for                          influenza
                                                        workers with                           illness
                                                        paid sick leave                        (adjusted
                                                        was                                    prevalence
                                                        approximately                          ratio (95%CI)
                                                        10–15% higher                          1.21 (1.01,
                                                                                               1.44)

Asfaw       USA         Survey         Expanded paid    workers with        Assuming 10–       NA                Paid sick leave    NA
2018                                   sick leave       paid sick leave     12% of days                          could save
                                                        spent an            absent due to                        employers
                                                        average of 1.10     illness, 0.026%                      $0.63 to
                                                        more days away      transmission                         $1.88 billion in
                                                        from work per       rate, and an                         reduced illness-
                                                        year due to         average daily                        related
                                                        illness or injury   contact of three                     absenteeism
                                                        (95% CI: 0.90 to    to five                              costs per year
                                                        1.30)]              coworkers, a
                                                                            worker at work
                                                                            due to lack of
                                                                            paid sick leave
                                                                            could infect on
                                                                            the average
                                                                            0.0405 to
                                                              Page 10/20
Author,       Country   Study Design   Economic         Public health      Population        General well-     Non-health          Equity impact
year                                   relief program   measure            health            being             outcomes
                                       type             impact             outcomes
                                                                           associated with
                                                                           public health
                                                                           measure
                                                                           impact
                                                                           0.0810
                                                                           coworkers per
                                                                           year.

Wilson        USA       Survey         Expanded paid    Adjusted odds      Decreased the     Universal paid    Universal paid      White non-
2014                                   sick leave       of having a        number of         leave is          leave averted       Hispanics
                                                        vaccination        influenza cases   predicted to      63.8 thousand       had higher
                                                        increased with     by 57 thousand    result in 18.2    workdays lost       odds of
                                                        paid leave vs.                       thousand          to influenza        receiving flu
                                                        without paid                         fewer             each year,          vaccination
                                                        leave (OR =                          healthcare                            than another
                                                        1.42, CI: 1.31–                      visits, for the                       race/ethnicity
                                                        1.53)                                flu annually.

Marinescu     USA       Survey         Unemployment     NA                 NA                NA                10% increase in     NA
2021                                   assistance                                                              unemployment
                                                                                                               benefits
                                                                                                               resulted in 3.6%
                                                                                                               decline in job
                                                                                                               applications

Kim 2020      South     Survey         Cash transfer    NA                 NA                NA                Cash voucher        NA
              Korea                                                                                            scheme
                                                                                                               increased
                                                                                                               consumption
                                                                                                               spending
                                                                                                               among 36% of
                                                                                                               the households.

Bienvenido-   Spain     Simulation     Mixed            NA                 NA                NA                Unemployment        NA
Huertas                                                                                                        aids could
2021                                                                                                           contribute to
                                                                                                               alleviating
                                                                                                               energy poverty,
                                                                                                               especially if the
                                                                                                               unemployed
                                                                                                               individual
                                                                                                               worked in a
                                                                                                               poorly paying
                                                                                                               job or for just a
                                                                                                               few hours.

Han 2020      USA       Simulation     Cash transfer    NA                 NA                NA                Government          NA
                                                                                                               cash program
                                                                                                               resulted in a
                                                                                                               decline in
                                                                                                               poverty during
                                                                                                               the COVID-19
                                                                                                               pandemic.

Karger        USA       Simulation     Cash transfer    NA                 NA                NA                $1,200 stimulus     NA
2021                                                                                                           payment
                                                                                                               disbursed
                                                                                                               increased
                                                                                                               consumer
                                                                                                               spending by
                                                                                                               $546.

Fang 2020     USA       Simulation     Unemployment     NA                 NA                NA                The CARES           NA
                                       assistance                                                              Unemployment
                                                                                                               Insurance
                                                                                                               policies
                                                                                                               reduced
                                                                                                               cumulative
                                                                                                               deaths by 4.9%.

Evangelist    USA       Survey         Unemployment     NA                 NA                NA                the                 NA
2022                                   assistance                                                              unemployment
                                                                                                               insurance
                                                                                                               declined health
                                                                                                               care services
                                                                                                               spending
                                                                                                               declined by 1%

Stiemele      USA       Survey         Food             NA                 NA                NA                Food insecurity     NA
2021                                   assistance                                                              decreased
                                                                                                               most among
                                                                                                               those who
                                                                                                               received the
                                                                                                               local food


                                                              Page 11/20
Author,      Country   Study Design    Economic         Public health     Population        General well-   Non-health         Equity impact
year                                   relief program   measure           health            being           outcomes
                                       type             impact            outcomes
                                                                          associated with
                                                                          public health
                                                                          measure
                                                                          impact
                                                                                                            assistance
                                                                                                            program

Raifman      USA       Retrospective   Unemployment     NA                NA                NA              unemployment       NA
2021                   observational   assistance                                                           insurance was
                                                                                                            associated with
                                                                                                            a 4.3%
                                                                                                            decrease in
                                                                                                            food insecurity
                                                                                                            and a 5.7%
                                                                                                            decrease in
                                                                                                            eating less due
                                                                                                            to financial
                                                                                                            constraints.

Kubota       Japan     Survey          Cash transfer    NA                NA                NA              Cash payments      NA
2021                                                                                                        increased was
                                                                                                            associated with
                                                                                                            a jump in
                                                                                                            spending rate

Fiang 2020   USA       Survey          Food             NA                NA                NA              The alternative    NA
                                       assistance                                                           school meals
                                                                                                            improved with
                                                                                                            food security
                                                                                                            for lower-
                                                                                                            income
                                                                                                            families.

Martin       USA       Simulation      Mixed            NA                NA                NA              Social             NA
2020                                                                                                        protection
                                                                                                            programs
                                                                                                            reduced the
                                                                                                            increase in
                                                                                                            poverty rates

Clay 2021    USA       Survey          Food             NA                NA                NA              Food               NA
                                       assistance                                                           assistance
                                                                                                            programs were
                                                                                                            associated with
                                                                                                            a higher
                                                                                                            likelihood of
                                                                                                            experiencing
                                                                                                            food insecurity
                                                                                                            (OR: 2.59
                                                                                                            (1.62,4.16).

Raifman      USA       Survey          Unemployment     NA                NA                NA              unemployment       NA
2020                                   assistance                                                           insurance was
                                                                                                            associated with
                                                                                                            a 4.4% decline
                                                                                                            in food
                                                                                                            insecurity, and
                                                                                                            6.1% decline in
                                                                                                            eating less due
                                                                                                            to financial
                                                                                                            constraints.

Bhutta,      USA       Survey          Mixed            NA                NA                NA              The CARES Act      NA
2020                                                                                                        improved
                                                                                                            households’
                                                                                                            financial
                                                                                                            security.

Men 2021     Canada    Survey          Mixed            NA                NA                NA              The applicants     NA
                                                                                                            of Canada
                                                                                                            Economic
                                                                                                            Response
                                                                                                            Benefit, regular
                                                                                                            Employment
                                                                                                            Insurance
                                                                                                            benefits, and
                                                                                                            other
                                                                                                            Employment
                                                                                                            Insurance
                                                                                                            benefits had
                                                                                                            2.53, 1.80, and
                                                                                                            3.01 times
                                                                                                            higher adjusted
                                                                                                            odds of food
                                                                                                            insecurity,
                                                                                                            respectively,
                                                             Page 12/20
Author,      Country     Study Design    Economic         Public health     Population        General well-   Non-health          Equity impact
year                                     relief program   measure           health            being           outcomes
                                         type             impact            outcomes
                                                                            associated with
                                                                            public health
                                                                            measure
                                                                            impact
                                                                                                              than non-
                                                                                                              applicants.

Madeira      Chile       Survey          Mixed            NA                NA                NA              Income and          NA
2021                                                                                                          expenses
                                                                                                              support
                                                                                                              program
                                                                                                              represented
                                                                                                              13.6% of the
                                                                                                              average
                                                                                                              households’
                                                                                                              permanent
                                                                                                              income of poor
                                                                                                              families in April
                                                                                                              2020

Breunig      Australia   Retrospective   Cash transfer    NA                NA                NA              Program             NA
2023                     observational                                                                        recipient had
                                                                                                              46% of their
                                                                                                              weekly pre-
                                                                                                              COVID‐19
                                                                                                              wages replaced
                                                                                                              by the
                                                                                                              transfers.

Choi 2022    South       Survey          Cash transfer    NA                NA                NA              The stimulus        NA
             Korea                                                                                            payments
                                                                                                              increased local
                                                                                                              consumption in
                                                                                                              establishments
                                                                                                              accepting the
                                                                                                              Gyeonggi local
                                                                                                              currency
                                                                                                              relative to other
                                                                                                              establishments.

Li 2022      USA         Survey          Food             NA                NA                NA              SNAP                NA
                                         assistance                                                           significantly
                                                                                                              reduced food
                                                                                                              insecurity by
                                                                                                              24.5% among
                                                                                                              households
                                                                                                              who were
                                                                                                              already food
                                                                                                              insufficient
                                                                                                              before the
                                                                                                              pandemic and
                                                                                                              by 11.9% for
                                                                                                              households
                                                                                                              with children.

Lowery       USA         Survey          Food             NA                NA                NA              Healthy Helping     NA
2022                                     assistance                                                           program was
                                                                                                              associated with
                                                                                                              a $26.95
                                                                                                              increase in
                                                                                                              monthly
                                                                                                              spending on
                                                                                                              fruit,
                                                                                                              vegetables,
                                                                                                              nuts, and
                                                                                                              legumes and
                                                                                                              other shifts in
                                                                                                              the
                                                                                                              composition of
                                                                                                              food
                                                                                                              purchases.

Park 2022    USA         Survey          Unemployment     NA                NA                NA              Unemployment        NA
                                         assistance                                                           insurance
                                                                                                              reduced
                                                                                                              mortgage debt
                                                                                                              payments.

Pilkauskas   USA         Randomized      Cash transfer    NA                NA                The cash        The cash            NA
2023                     controlled                                                           transfer        transfer
                         trial                                                                program had     program had no
                                                                                              no impact on    impact on
                                                                                              mental health   material
                                                                                                              hardship,
                                                                                                              parenting, child
                                                                                                              behavior,

                                                               Page 13/20
 Author,         Country       Study Design      Economic          Public health       Population         General well-      Non-health          Equity impact
 year                                            relief program    measure             health             being              outcomes
                                                 type              impact              outcomes
                                                                                       associated with
                                                                                       public health
                                                                                       measure
                                                                                       impact
                                                                                                                             partner
                                                                                                                             relationships,
                                                                                                                             hardship
                                                                                                                             avoidance,
                                                                                                                             consumption,
                                                                                                                             employment,
                                                                                                                             and benefit use

 Wahdat          USA           Survey            Cash transfer     NA                  NA                 NA                 Economic            NA
 2022                                                                                                                        Impact
                                                                                                                             Payment was
                                                                                                                             associated with
                                                                                                                             9.2% decrease
                                                                                                                             in food
                                                                                                                             insufficiency.

Insert Table 1

Limitations associated with individual-level economic relief programs.

Three studies discussed the limitations of their respective programs (18, 27, 54). Limitations associated with unemployment assistance programs in two
studies included state-level variability in unemployment insurance benefits (18), the complexity of the unemployment insurance program structure, the
presence of barriers that prevent eligible individuals from receiving program benefits (18), and issues related to eligibility and implementation challenges,
such as erroneous data on unemployment rate (27). In a COVID-19 cash transfer program study, the authors suggested that the implemented consumption
voucher program could constrain consumer choice and possibly harm consumer welfare and economic efficiency in the long run because beneficiaries could
only redeem the vouchers at small business stores (54).
Knowledge gap
Our review identified four key knowledge gaps:

Limited disease focus. All eligible studies were on COVID-19 and influenza. Despite the occurrence of SARS, H1N1 influenza, MERS, Ebola, Zika and West Nile
Virus outbreaks during eligibility period, we did not identify any eligible study on these outbreaks in our review.

Lack of evidence on the effect of unemployment assistance programs and food assistance programs on public health measures (such as physical
distancing, quarantine/isolation, vaccination). Among the unemployment assistance programs and food assistance programs studies included in our review,
none reported on public health measure impact.

Limited evidence of the impact of individual-level economic relief programs on equity. Only 16% of eligible studies reported on the equity impact. None of the
eight studies that assessed the equity impact of unemployment assistance programs, vaccine incentive programs, “other” programs, and cash transfer
programs reported the program's effect on relevant equity variables. The impact of expanded paid sick leave programs and food assistance programs on
equity remains undetermined.

Lack of evidence on the long-term effect of individual-level economic relief programs on health outcomes, which were not considered in the 36 eligible
studies that reported health outcomes. Assessing the long-term health effects of individual-level economic relief policies, particularly post-pandemic during
the recovery stage, could provide insight into the importance of the programs to equity and societal well-being.


DISCUSSION
Our review charts the current state of the literature on the types of individual-level economic relief programs implemented during infectious disease
outbreaks. Overall, our review has four key findings.

First, our finding suggests a concentration of studies conducted in the USA. The predominance of studies in the USA is striking and may indicate protection
of its vulnerable population (70) from the “lockdown” effect in the context of historically lower investment on social protection programs pre-pandemic
compared to other G7 countries (71).

Second, expanded paid sick leave was found to have a consistent pattern of improved health outcomes. Our findings corroborate the findings of a recent
meta-analysis study of 12 studies, reporting that paid sick leave was associated with increased odds of following public health directives (vaccine uptake)
and seeking medical care (72).

Third, individual-level economic relief programs improved population health outcomes among equity-deserving populations. The improved health outcomes
observed among equity seeking populations is likely due to their improved adherence to public health measures enabled by economic relief programs. (73).




                                                                         Page 14/20
Lastly, most individual-level economic relief program types positively impacted mental health, re-affirming the long-established evidence of the relationship
between financial well-being and psychological well-being (74, 75). Non-health outcomes associated with the programs had beneficial impact on key
domains of social determinants of health i.e., economic stability and healthcare access and quality. Addressing social determinants of health is fundamental
for improving health and reducing longstanding inequities in societal health (76).

Our review has some limitations. First, we restricted our search strategy to studies in high-income countries due to the high volume of studies. Future reviews
should synthesize the impact of similar programs in low-and middle-income countries. Second, due to the volume of studies identified we were only able to
focus on selected infectious diseases. This limitation makes our findings disease-specific, requiring careful interpretation if attempting to extrapolate
findings to other infectious diseases (e.g., HIV). Further, we did not search the grey literature and only included publications in English. Our findings may
therefore be biased towards English-speaking high-income settings.

Our review’s strength lies in our use of a rigorous scoping review methodology. Screening and data extraction forms were pretested by all reviewers and
revised as needed to ensure they are adequately sensitive to capture outcomes in eligible studies. We searched multiple relevant electronic scientific
databases to ensure our results were comprehensive and accurate. Lastly, our eligibility criteria had no restriction on study design.

Our findings provide compelling evidence that individual-level economic relief programs provide broad and positive impact on public health measures,
population health, general well-being, equity, and social determinants of health (e.g., economic stability).

As countries prepare for future pandemics, our findings provide evidence to stakeholders to recognize health equity as a fundamental public health goal
when designing pandemic preparedness policies.


CONCLUSION
Individual-level economic relief programs implemented during epidemics/pandemics significantly impacted public health measures, outbreak-related
population health outcomes and health equity. Our findings can inform investments in individual-level economic relief programs to protect population health
in future pandemics, particularly for equity-seeking populations, to prevent the widening of pre-existing societal inequity.


Declarations
Ethics approval and consent to participate: Not applicable.

Consent for publication: Not applicable

Availability of data and materials: All data generated or analysed during this study are included in this published article and its supplementary information
files.

Competing interests: The authors declare that they have no competing interests.

Funding: The preparation of the manuscript was supported by Emerging and Pandemic Infections Consortium, University of Toronto

Authors' contributions: AO and BS conceptualized the study. AF acquired the data. AO, GBG, AP and MH screened and analyzed the data. AO, KL, SM, BS
interpreted the data. AO drafted the manuscript. AF, SM, KL and BS revised the manuscript. All authors read and approved the final manuscript.


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Figures




Figure 1

Preferred Reporting Items in Systematic Reviews and Meta-Analyses (PRISMA) flowchart




                                                                       Page 18/20
Figure 2

Heat map depicting program and studies characteristics of included studies

Footnotes: [The number of studies by individual-level economic relief program type and country are ordered from highest to lowest (left to right). We
assigned dark to light colours to depict a no study scenario to having more than 6 studies scenarios].




                                                                        Page 19/20
Figure 3

Coxcomb Chart depicting study outcomes by individual-level economic relief program type

Footnotes: [The different colours of the ray indicate the various components of the review outcomes. The width of the ray indicates the impact of the
individual-level economic relief program type on the components of the review outcomes. A wide width implies that the individual-level economic relief
program type has a positive impact on the specific review outcome assessed and a narrow width denotes a negative impact.]


Supplementary Files
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    AppendixdataOriginalMEDLINEsearchstrategy.20012021.docx
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